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FLASH GENE
Symbol HOXD@ contributors: mct - updated : 01-10-2009
HGNC name homeo box D cluster
HGNC id 5131
Corresponding disease
DEL2Q31 chromosome 2q interstitial deletion, including 2q31.1
DUP2QM chromosome 2q interstitial duplication, including 2q31.1
MMDK mesomelic dysplasia, Kantaputra type
Location 2q31      Physical location : -
Synonym name
  • homeo box region D (9 genes), patterning the primary and secondary axes of developing mouse embryo
    • Synonym symbol(s) HOX4, HOX4@
    DNA
    TYPE cluster
    MAPPING cloned Y linked   status confirmed
    Map cen - FRA2G - DLX1 ,DLX2 - EVX2 - HOXD13 (HOX4I ) - HOXD12 (HOX4H ) - HOXD11 (HOX4F ) - HOXD10 (HOX4D ) - FRA2H - HOXD9 (HOX4C ) - HOXD8 (HOX4E ) - HOXD4 (HOX4B ) - HOXD3 (HOX4A ) - HOXD1 (HOX4G ) - qter
    Authors Murtha (91), Scott (92), Limongi (00)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • required for proper limb development
  • play an established role in bone development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMDK , DUP2QM , DEL2Q31
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS