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FLASH GENE
Symbol HOXD1 contributors: mct/npt/pgu - updated : 11-09-2009
HGNC name homeobox D1
HGNC id 5132
Location 2q31-q37      Physical location : 177.053.306 - 177.055.635
Synonym name
  • homeo box D1
  • homeo box 4G
    • Synonym symbol(s) HOX4G, HOX4, HXD1, Hox-4.7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 2.33 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - EVX2 - HOXD13 - HOXD4 - HOXD3 - HOXD1 - MTX2 - qter
    Text see HOXD@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1991 - 328 - 2000 11060466
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   predominantly Homo sapiens
    Nervousbrain   moderately
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain, homeobox domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.9
    homolog to Drosophila lab
    Homologene
    FAMILY
  • ANTP family of homeobox protein
  • labial subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in both axial patterning and limb morphogenesis
  • possible role for HOXD1 in the ovarian oocytes and the establishment of mesodermal derivatives during embryogenesis
  • potential synergy between MEIS3 and HOXD1 in HOXD1 autoregulation in mesoderm during gastrulation
  • plays a significant role in endothelial cells functions by regulating the expression of ITGB1
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MOG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS