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FLASH GENE
Symbol HOXD1 contributors: mct/npt/pgu - updated : 11-09-2009
HGNC name homeobox D1
HGNC id 5132
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1991 - 328 - 2000 11060466
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly Homo sapiens
Nervousbrain   moderately
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain, homeobox domain
  • HOMOLOGY
    interspecies homolog to murine Hox-4.9
    homolog to Drosophila lab
    Homologene
    FAMILY
  • ANTP family of homeobox protein
  • labial subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in both axial patterning and limb morphogenesis
  • possible role for HOXD1 in the ovarian oocytes and the establishment of mesodermal derivatives during embryogenesis
  • potential synergy between MEIS3 and HOXD1 in HOXD1 autoregulation in mesoderm during gastrulation
  • plays a significant role in endothelial cells functions by regulating the expression of ITGB1
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MOG
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS