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FLASH GENE

Symbol

HOXC8

contributors: mct - updated : 28-01-2009

HGNC name	homeo box C8
HGNC id	5129

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.13      Physical location : 54.402.889 - 54.406.543
Synonym name	homeo box C8(3A)
Synonym symbol(s)	HOX3, HOX3A

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	3.65 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   transcription factor
text structure	a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D12S881 - D12S1507 - HOXC8 - D12S325 - D12S1961 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 2290 - 242 - Kikugawa (2006)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies

homolog to murine Hox-3.1

Homologene

FAMILY

homeodomain protein family

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in mouse anterior and posterior patterning and innervation of the limb
	playing a role in the acquisition of invasive and metastatic prostate cancer
	may play a role in the regulation of cartilage differentiation
	acting as a transcriptional regulator in a variety of developmental processes during embryogenesis (Kong 2008)
	blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor NCOA3)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

complexing with PBX1 (PBX1-HOXC8 heterocomplex may lead to androgen-independent growth in prostate cancer) (Kikugawa 2006)

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer with loss of differentiation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS