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FLASH GENE
Symbol HOXC8 contributors: mct - updated : 28-01-2009
HGNC name homeo box C8
HGNC id 5129
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-3.1
Homologene
FAMILY homeodomain protein family
CATEGORY transcription factor , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in mouse anterior and posterior patterning and innervation of the limb
  • playing a role in the acquisition of invasive and metastatic prostate cancer
  • may play a role in the regulation of cartilage differentiation
  • acting as a transcriptional regulator in a variety of developmental processes during embryogenesis (Kong 2008)
  • blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor NCOA3)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component complexing with PBX1 (PBX1-HOXC8 heterocomplex may lead to androgen-independent growth in prostate cancer) (Kikugawa 2006)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with loss of differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS