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FLASH GENE
Symbol HOXA5 contributors: mct - updated : 19-05-2012
HGNC name homeobox A5
HGNC id 5106
Location 7p15.2      Physical location : 27.180.995 - 27.183.287
Synonym name homeo box A5(1C)
Synonym symbol(s) HOX1C, HOX1.3, HOX1, MGC9376
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • homeobox gene A cluster
  • STRUCTURE 2.62 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HOXA@
    Physical map
    LOC392006 7 similar to Rpl7a protein SND1 7q31.3 similar to Rpl7a protein LOC346416 7p15.2 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) LOC221875 7p15.2 similar to tropomyosin 3 LOC392007 7 similar to nucleolar protein family A, member 2; component of the H/ACA snoRNP HOXA1 7p15.3 homeo box A1 HOXA2 7p15.3 homeo box A2 HOXA3 7p15.3 homeo box A3 LOC392647 7 similar to mKIAA0038 protein LOC392879 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 HOXA4 7p15.3 homeo box A4 HOXA5 7p15.3 homeo box A5 HOXA6 7p15.3 homeo box A6 LOC392880 7 similar to hypothetical protein MGC2574 HOXA7 7p15.3 homeo box A7 HOXA9 7p15.3 homeo box A9 HOXA10 7p15.3 homeo box A10 HIBADH 7p15.2 3-hydroxyisobutyrate dehydrogenase HOXA11 7p15.3 homeo box A11 HOXA11S 7p15.2 homeo box A11, antisense HOXA13 7p15.3 homeo box A13 EVX1 7p15-p14 eve, even-skipped homeo box homolog 1 (Drosophila) LOC392008 7 similar to 60S ribosomal protein L35 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1657 - 270 - 2005 15757903
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  moderately
     mouth   highly
    Endocrineneuroendocrinepituitary  moderately
    Reproductivemale systemtestis  highly
    Respiratorylung   moderately Homo sapiens
     respiratory tracttrachea  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text during early myelopoiesis, during embryogenesis and predominantly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an homeobox DNA binding domain
  • a protein transduction domain, with a role in protein transduction that may be useful in the suppression of vascular activation or vascular inflammatory disorders
  • secondary structure helix-turn-helix
    HOMOLOGY
    interspecies homolog to rattus Hoxa5 (97.8 pc)
    homolog to murine Hoxa5 (97.8 pc)
    intraspecies paralog to HOXB5
    Homologene
    FAMILY
  • Antp homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • upregulating both TP53 promoter-reporter constructs and endogenous P53 synthesis
  • inhibiting erythropoiesis
  • promoting myelopoiesis
  • involved in the regulation of hematopoietic lineage determination and maturation
  • central role for HOXA5 in coordinating a stable vascular phenotype
  • playing an important role in tumorigenesis step in growth and homeostasis in breast cells
  • absent in activated angiogenic endothelial cells and can block angiogenesis
  • can specifically activate the pleiotrophin promoter
  • regulates both TP53 and progesterone receptor expression levels in breast cancer cells
  • may play a role in maintaining the differentiated state within the breast epithelium
  • stroma-specific gene, playing a significant role in ovarian biology and may be involved in ovarian cancer predisposition
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • HOXA5 and HOXB5 paralog genes shared some functions during lung morphogenesis, but HOXA5 playing a predominant role
  • is required for forelimb anterior patterning
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding specifically to the motif 5'-CYYNATTA[TG]Y-3'
  • binding to its own promoter
  • RNA
    small molecule
    protein
  • TP53, PR
  • transactivator of progesterone receptor
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
  • cell & other
    REGULATION
    activated by transcriptionally activated by all-trans retinoic acid (RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nearly 70 p100 of all breast carcinomas
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia, but low level of HOXA5 hypermethylation is associated with short-term outcome
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene of androgen-mediated promoter methylation
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deregulation of the estrous cycle and the presence of ovarian epithelial cysts in Hoxa5(-/-) older murine females correlate with a reduced expression of specific epidermal growth factor receptor signaling components, namely Egfr, Areg, and Btc