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FLASH GENE
Symbol HOXA5 contributors: mct - updated : 19-05-2012
HGNC name homeobox A5
HGNC id 5106
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1657 - 270 - 2005 15757903
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  moderately
 mouth   highly
Endocrineneuroendocrinepituitary  moderately
Reproductivemale systemtestis  highly
Respiratorylung   moderately Homo sapiens
 respiratory tracttrachea  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text during early myelopoiesis, during embryogenesis and predominantly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA binding domain
  • a protein transduction domain, with a role in protein transduction that may be useful in the suppression of vascular activation or vascular inflammatory disorders
  • secondary structure helix-turn-helix
    HOMOLOGY
    interspecies homolog to rattus Hoxa5 (97.8 pc)
    homolog to murine Hoxa5 (97.8 pc)
    intraspecies paralog to HOXB5
    Homologene
    FAMILY
  • Antp homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • upregulating both TP53 promoter-reporter constructs and endogenous P53 synthesis
  • inhibiting erythropoiesis
  • promoting myelopoiesis
  • involved in the regulation of hematopoietic lineage determination and maturation
  • central role for HOXA5 in coordinating a stable vascular phenotype
  • playing an important role in tumorigenesis step in growth and homeostasis in breast cells
  • absent in activated angiogenic endothelial cells and can block angiogenesis
  • can specifically activate the pleiotrophin promoter
  • regulates both TP53 and progesterone receptor expression levels in breast cancer cells
  • may play a role in maintaining the differentiated state within the breast epithelium
  • stroma-specific gene, playing a significant role in ovarian biology and may be involved in ovarian cancer predisposition
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • HOXA5 and HOXB5 paralog genes shared some functions during lung morphogenesis, but HOXA5 playing a predominant role
  • is required for forelimb anterior patterning
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding specifically to the motif 5'-CYYNATTA[TG]Y-3'
  • binding to its own promoter
  • RNA
    small molecule
    protein
  • TP53, PR
  • transactivator of progesterone receptor
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
  • cell & other
    REGULATION
    activated by transcriptionally activated by all-trans retinoic acid (RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nearly 70 p100 of all breast carcinomas
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia, but low level of HOXA5 hypermethylation is associated with short-term outcome
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene of androgen-mediated promoter methylation
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deregulation of the estrous cycle and the presence of ovarian epithelial cysts in Hoxa5(-/-) older murine females correlate with a reduced expression of specific epidermal growth factor receptor signaling components, namely Egfr, Areg, and Btc