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FLASH GENE
Symbol HOXA10 contributors: mct - updated : 15-06-2016
HGNC name homeobox A10
HGNC id 5100
Corresponding disease
HOXA10 T-cell acute lymphoblastic leukemia (T-ALL)
Location 7p15.2      Physical location : 27.210.210 - 27.219.876
Synonym name
  • centaurin alpha1- like
  • homeobox protein 1H
  • homeobox protein HOXA10
    • Synonym symbol(s) HOX1H, HOX1, HXAA, PL, HOX1.8, MGC12859
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 9.67 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure
  • two estrogen response element (ERE1 and ERE2) that mediated differential ligand-specific estrogen-responsive transcriptional activation, and which are close to the transcription start site, and are associated with E2-mediated activation of HOXA10
  • a specificity protein 1 (Sp1) binding site
  • a CDX4-binding cis element that activated the HOXA10 promoter
    • MAPPING cloned Y linked   status provisional
    Map see HOXA@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 2648 - 410 - 2007 17234739
    2 splicing 2272 - 94 - 2007 17234739
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   highly
    Reproductivefemale systemuterus  highly
     female systembreastmammary gland highly
     male systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone   
    Epithelialbarrier/liningendometrium  
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing uterus, expressed in the embryonic paramesonephric (Müllerian) ducts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-1.8
    Homologene
    FAMILY
  • ABD-B homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be regulating gene expression, morphogenesis, and differentiation
  • playing a pivotal role in normal hematopoietic-lineage determination and regulation
  • involved in regulating decidualization
  • master regulator of postnatal hematopoietic development
  • had an important role in induction of apoptosis by the Abl kinase inhibitors in chronic myelogenous leukemia cells
  • transcription factor that is crucial for development and patterning of the uterus during embryogenesis
  • required for uterine receptivity and implantation, and is a key regulator of decidualization )
  • early activator of bone gene expression which functions by facilitating the remodeling of chromatin
  • major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via polycomb repressor complex 2 (PRC2) which therefore contributes to T-cell leukemogenesis
  • facilitates myeloid progenitor expansion and impedes myeloid differentiation
  • is a homeodomain transcription factor that is involved in maintenance of the myeloid progenitor population and implicated in myeloid leukemogenesis
  • HOXA10 and HOXA13 are involved in the development of human genitalia
  • role for HOXA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox proteins to the innate immune response
  • HOXA10 and EMX2 are two transcription factors necessary for female Müllerian duct differentiation and development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIRT2
  • CAPN5 is a target of HOXA10 transcriptional regulation in endometrial cells
  • target of PHGDH regulation in endometrial cells
  • DUSP4 is a HOXA10 target gene
  • interaction with PBX1 (acting to reduce HOXA10-mediated transcriptional activation at bone-specific promoters)
  • TGFB2 is a HOXA10 target gene (HOXA10 activated TGFB2 transcription by interacting with tandem cis elements in the promoter)
  • ARIH2 has E3 ubiquitin ligase activity, and HOXA10-overexpressing myeloid cells exhibited a ARIH2-dependent increase in protein ubiquitination
  • CDX4 influenced transcription of HOXA10 target genes in a HOXA10-dependent manner
  • HOXA10 activates ITGB3 transcription in myeloid progenitor cells and differentiating phagocytes
  • FGF2 expression and secretion are regulated in a HOXA10-dependent manner in myeloid progenitor cells and differentiating phagocytes
  • HOXA9, HOXA10 are direct transcriptional targets of SETBP1
  • FGF2 and CDX4 are direct target genes of HOXA10 and HOXA10 is a CDX4 target gene
  • CTNNB1 activates the HOXA10 and CDX4 genes in myeloid progenitor cells
  • NKX2-5 mediates differential cardiac differentiation through interaction with HOXA10
  • HOXA10-mediated expression of MMP26 promotes embryo adhesion during the process of embryonic implantation
  • KMT2A collaborate with ESR1 to regulate HOXA10 expression in AML
  • CDX4 activates transcription of the HOXA9 and HOXA10 genes, and HOXA10 activates CDX4 transcription
  • HOXA10 actives transcription of the gene encoding ARIH2 during myeloid differentiation
  • EMX2 gene is a known direct target of HOXA10 in the reproductive tract
    • cell & other
    REGULATION
    repressed by progesterone in myometrium
    Other regulated by the testosterone
    regulated by 17ß-estradiol (E2) and progesterone
    ASSOCIATED DISORDERS
    corresponding disease(s) HOXA10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in polycystic ovary syndrome (PCOS), contributing to the diminished reproduction potential of women
    tumoral     --over  
    promoter hypomethylation is an important mechanism for high expression of HOXA10 in ovarian cancer and may be a potential prognostic factor in ovarian cancer
    tumoral     --over  
    in poor prognosis human AML(acute myeloid leukemia), and HOXA10 overexpression in myeloid progenitor cells increased TGFB2 production by the cells
    tumoral     --over  
    of HOXA9 and HOXA10 and their essential cofactor MEIS1 in cells with the t(4;11) chromosome translocation and MLL-AF4 in acute leukemia
    tumoral     --over  
    increases FGF2 mRNA expression and FGF2 protein secretion in U937 myeloid leukemia cells
    tumoral     --over  
    in prostate cancer cell lines and tissues compared to those in normal prostate epithelium
    Susceptibility to genital malformations
    Variant & Polymorphism other rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia
    Candidate gene DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with Hoxa10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow