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GENATLAS PHENOTYPE
last update : 18/10/06
Symbol HOXA10
Location 7p15.2 and 7q34
Name T-cell acute lymphoblastic leukemia (T-ALL)
Corresponding gene HOXA10 , TCRBVS
Main clinical features
  • leukemia with acquired chromosomal rearrangements and breakpoints in 7p15 and 7q34
    • Genetic determination
    Function/system disorder hematology
    neoplasia
    Type malignancy
    Remark(s) acquired inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRbeta) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute lymphoblastic leukemia (T-ALL) patients leading to transcriptional activation of especially HOXA10