Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HOOK3 contributors: mct/pgu - updated : 23-01-2009
HGNC name hook homolog 3 (Drosophila)
HGNC id 23576
Location 8p11.21      Physical location : 42.752.032 - 42.885.681
Synonym name golgi-associated microtubule-binding protein HOOK3
Synonym symbol(s) HK3, FLJ31058
DNA
TYPE functioning gene
STRUCTURE 122.90 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D8S532 - D8S268 - HOOK3 - cen - D8S531 - D8S519 - qter
Authors UCSC (2009)
Physical map
SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase FLJ25169 8p11.21 hypothetical protein FLJ25169 ANK1 8p11.2 ankyrin 1, erythrocytic MYST3 8p11 MYST histone acetyltransferase (monocytic leukemia) 3 AP3M2 8p11.2 adaptor-related protein complex 3, mu 2 subunit PLAT 8p12-p11.2 plasminogen activator, tissue LOC389650 8 LOC389650 IKBKB 8p11.2 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta POLB 8p11.2 polymerase (DNA directed), beta DKK4 8p11.2-p11.1 dickkopf homolog 4 (Xenopus laevis) VDAC3 8q11.2 voltage-dependent anion channel 3 SLC20A2 8p12-q21 solute carrier family 20 (phosphate transporter), member 2 LOC114926 8p11.21 hypothetical protein BC013035 CHRNB3 8p11.2 cholinergic receptor, nicotinic, beta polypeptide 3 CHRNA6 8p22 cholinergic receptor, nicotinic, alpha polypeptide 6 THAP1 8p11.1 THAP domain containing, apoptosis associated protein 1 DKFZP564A022 8p11.21 hypothetical protein DKFZp564A022 HOOK3 8p11.21 hook homolog 3 (Drosophila) FNTA 8p22-q11 farnesyltransferase, CAAX box, alpha FLJ23356 8p11.21 hypothetical protein FLJ23356 FLJ32731 8p11.1 hypothetical protein FLJ32731 LOC347028 8p11.21 similar to AFG3-like protein 2 (Paraplegin-like protein) LOC340441 8p11.21 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389651 8 similar to hypothetical protein (L1H 3 region) - human
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 14460 83 718 - 2010 20152126
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Nervousbrainmidbrainhypothalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervouscentralwhite matter  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an acidic N-terminal globular domain
  • an extended central coiled-coil motif
  • a basic C-terminal globular domain
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Hook3 (95.7 pc)
    homolog to murine Hook3 (97.8 pc)
    intraspecies homolog to HOOK1 and HOOK2
    Homologene
    FAMILY
  • hook family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text cis-Golgi network
    basic FUNCTION
  • required for protein transport from the ER to the golgi complex
  • involved in tethering the Golgi complex to the cytoskeleton
  • participating in defining the architecture and localization of the Golgi complex
  • HOOK3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with spiC from Salmonella typhimurium
  • interaction between HOOK3 and PCM1 required by trafficking of pericentriolar satellites
  • cell & other
  • interacting with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with RET in papillary thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS