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FLASH GENE
Symbol HOOK3 contributors: mct/pgu - updated : 23-01-2009
HGNC name hook homolog 3 (Drosophila)
HGNC id 23576
DNA
TYPE functioning gene
STRUCTURE 122.90 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D8S532 - D8S268 - HOOK3 - cen - D8S531 - D8S519 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 14460 83 718 - 2010 20152126
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Nervousbrainmidbrainhypothalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervouscentralwhite matter  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an acidic N-terminal globular domain
  • an extended central coiled-coil motif
  • a basic C-terminal globular domain
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Hook3 (95.7 pc)
    homolog to murine Hook3 (97.8 pc)
    intraspecies homolog to HOOK1 and HOOK2
    Homologene
    FAMILY
  • hook family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text cis-Golgi network
    basic FUNCTION
  • required for protein transport from the ER to the golgi complex
  • involved in tethering the Golgi complex to the cytoskeleton
  • participating in defining the architecture and localization of the Golgi complex
  • HOOK3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with spiC from Salmonella typhimurium
  • interaction between HOOK3 and PCM1 required by trafficking of pericentriolar satellites
  • cell & other
  • interacting with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with RET in papillary thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS