basic FUNCTION
| nucleosomal binding protein altering the structure of the chromatin fiber and enhancing transcription, only from chromatin templates |
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released from chromatin in the absence of transcription |
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acting as a molecular switch regulating homeodomain transcriptional activity |
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may be required in tissues or cells undergoing proliferation and differentiation during organogenesis |
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major regulator of homeodomain transcription factor activity modulated by WNT/CTNNB signaling |
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potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins (Rattner 2009) |
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act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility (Rattner 2009) |
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nuclear proteins that bind to nucleosomes and alter the structure of chromatin (Subramanian 2009) |
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facilitates the ability of the DNA repair proteins to access and repair UV-induced DNA lesions in chromatin (Subramanian 2009) |
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HMGN1, 2, and 3, promote astrocyte differentiation of neural precursor cells (NPCs) during brain development |
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HMGN1, HMGN2, HMGN3 are novel chromatin regulatory factors that control astrocyte fate decision/differentiation in parallel with or downstream of the JAK-STAT pathway |