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FLASH GENE
Symbol HMGN2 contributors: mct/npt - updated : 22-03-2015
HGNC name high-mobility group nucleosomal binding domain 2
HGNC id 4986
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 salivary gland   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemuteruscervix highly
Respiratorylung   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Hmgn2
Homologene
FAMILY
  • HMG14/HMG17 protein family
  • HMGN family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text inner segment
    basic FUNCTION
  • nucleosomal binding protein altering the structure of the chromatin fiber and enhancing transcription, only from chromatin templates
  • released from chromatin in the absence of transcription
  • acting as a molecular switch regulating homeodomain transcriptional activity
  • may be required in tissues or cells undergoing proliferation and differentiation during organogenesis
  • major regulator of homeodomain transcription factor activity modulated by WNT/CTNNB signaling
  • potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins (Rattner 2009)
  • act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility (Rattner 2009)
  • nuclear proteins that bind to nucleosomes and alter the structure of chromatin (Subramanian 2009)
  • facilitates the ability of the DNA repair proteins to access and repair UV-induced DNA lesions in chromatin (Subramanian 2009)
  • HMGN1, 2, and 3, promote astrocyte differentiation of neural precursor cells (NPCs) during brain development
  • HMGN1, HMGN2, HMGN3 are novel chromatin regulatory factors that control astrocyte fate decision/differentiation in parallel with or downstream of the JAK-STAT pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PITX2/HMG-17 regulatory complex acting independently of promoter targets and is a general mechanism for the control of homeodomain transcriptional activity
  • component of the global genome repair subpathway of the nucleotide excision repair pathway (Subramanian 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SENP1 can deSUMOylate SUMOylated HMGN2, and PIAS1 is the E3 ligase responsible for SUMOylation of HMGN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in dilated cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS