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Symbol HMGN1 contributors: mct/npt/pgu - updated : 26-02-2016
HGNC name high-mobility group nucleosome binding domain 1
HGNC id 4984
Location 21q22.2      Physical location : 40.714.246 - 40.721.047
Synonym name
  • high-mobility group (nonhistone chromosomal) protein 14
  • high-mobility group nucleosome binding 1
  • Synonym symbol(s) HMG14, FLJ27265, FLJ31471, MGC104230, MGC117425
    TYPE functioning gene
    STRUCTURE 6.81 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see IFNAR1
    Physical map
    DSCR9 21q22.13 Down syndrome critical region gene 9 DSCR3 21q22.3 Down syndrome critical region gene 3 DYRK1A 21q22.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A KCNJ6 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 6 DSCR4 21q22.2 Down syndrome critical region gene 4 DSCR8 21q22.2 Down syndrome critical region gene 8 DSCR10 21q22.2 Down syndrome critical region gene 10 KCNJ15 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 15 LOC388824 21 LOC388824 ERG 21q22.2 v-ets erythroblastosis virus E26 oncogene like (avian) ETS2 21q22.3 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) LOC391282 21 similar to 60S ribosomal protein L23a PCBP2P1 21q22.3 poly(rC) binding protein 2, pseudogene 1 DSCR2 21q22.3 Down syndrome critical region gene 2 C21orf107 21 chromosome 21 open reading frame 107 C21orf87 21q22.1 chromosome 21 open reading frame 87 HMGN1 21q22.3 high-mobility group nucleosome binding domain 1 WRB 21q22.3 tryptophan rich basic protein MGC33295 21q22.2 hypothetical protein MGC33295 SH3BGR 21q22.3 SH3 domain binding glutamic acid-rich protein B3GALT5 21q22.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 LOC388825 21 LOC388825 LOC150084 21q22.2 hypothetical protein LOC150084 PCP4 21q22.2-q22.3 Purkinje cell protein 4 DSCAM 21q22.2-q22.3 Down syndrome cell adhesion molecule LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1313 - 100 - 2009 19524541
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    at STAGE
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    text nuclear protein that binds specifically to nucleosomes
    basic FUNCTION
  • nucleosomal binding protein altering the structure of the chromatin fiber and enhancing transcription, only from chromatin templates
  • modulates the level of histone H2A phosphorylation
  • modulating histone posttranslational modifications, and histone H3 phosphorylation
  • alters the compaction of the chromatin fiber, increases the cellular sensitivity to ionizing radiation, optimizes the cellular response to ionizing radiation and to other tumorigenic event
  • altering the equilibrium generated by the opposing enzymatic activities that continuously modify and de-modify the histone tails in nucleosomes
  • playing a role on chromatin structure but does not affect SWI/SNF-dependent chromatin remodeling on either mononucleosomes or nucleosomal arrays
  • abundant nucleosomal binding protein, that can affect both the chromatin higher order structure and the modification of nucleosomal histones, but it alters the expression of only a subset of genes
  • regulates the expression of particular genes via specific protein-protein interactions with transcription factors at target gene regulatory regions
  • potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins
  • act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility
  • nuclear proteins that bind to nucleosomes and alter the structure of chromatin
  • play a role in global DNA repair expands the role of these proteins in the maintenance of genome integrity
  • modulates the interaction of ATM with chromatin both before and after double-stranded breaks formation, thereby optimizing its activation
  • is potentially part of the cellular machinery that modulates transcriptional fidelity by generating, maintaining, or preferentially interacting with specific sites in chromatin
  • nucleosome-binding protein ubiquitously expressed in vertebrate cells, that preferentially binds to CpG island-containing promoters and affects the organization of nucleosomes
  • HMGN1, 2, and 3, promote astrocyte differentiation of neural precursor cells (NPCs) during brain development
  • HMGN1, HMGN2, HMGN3 are novel chromatin regulatory factors that control astrocyte fate decision/differentiation in parallel with or downstream of the JAK-STAT pathway
  • contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines
    a component
    DNA binding
    small molecule
  • specifically interacts with estrogen receptor alpha ESR1 (at the TFF1 promoter, estrogen increases HMGN1 association through recruitment by ESR1)
  • HMGN1 is a new PCNA-interacting protein that enhances the binding of PCNA to chromatin but not to purified DNA
  • regulatory role for HMGN1 in PARP1 activation
  • is a potent alarmin that binds TLR4 and induces antigen-specific Th1 immune responses
  • cell & other