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FLASH GENE
Symbol HMGN1 contributors: mct/npt/pgu - updated : 26-02-2016
HGNC name high-mobility group nucleosome binding domain 1
HGNC id 4984
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunethymus   highly
Reproductivefemale systemuterus  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome,nucleosome
text nuclear protein that binds specifically to nucleosomes
basic FUNCTION
  • nucleosomal binding protein altering the structure of the chromatin fiber and enhancing transcription, only from chromatin templates
  • modulates the level of histone H2A phosphorylation
  • modulating histone posttranslational modifications, and histone H3 phosphorylation
  • alters the compaction of the chromatin fiber, increases the cellular sensitivity to ionizing radiation, optimizes the cellular response to ionizing radiation and to other tumorigenic event
  • altering the equilibrium generated by the opposing enzymatic activities that continuously modify and de-modify the histone tails in nucleosomes
  • playing a role on chromatin structure but does not affect SWI/SNF-dependent chromatin remodeling on either mononucleosomes or nucleosomal arrays
  • abundant nucleosomal binding protein, that can affect both the chromatin higher order structure and the modification of nucleosomal histones, but it alters the expression of only a subset of genes
  • regulates the expression of particular genes via specific protein-protein interactions with transcription factors at target gene regulatory regions
  • potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins
  • act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility
  • nuclear proteins that bind to nucleosomes and alter the structure of chromatin
  • play a role in global DNA repair expands the role of these proteins in the maintenance of genome integrity
  • modulates the interaction of ATM with chromatin both before and after double-stranded breaks formation, thereby optimizing its activation
  • is potentially part of the cellular machinery that modulates transcriptional fidelity by generating, maintaining, or preferentially interacting with specific sites in chromatin
  • nucleosome-binding protein ubiquitously expressed in vertebrate cells, that preferentially binds to CpG island-containing promoters and affects the organization of nucleosomes
  • HMGN1, 2, and 3, promote astrocyte differentiation of neural precursor cells (NPCs) during brain development
  • HMGN1, HMGN2, HMGN3 are novel chromatin regulatory factors that control astrocyte fate decision/differentiation in parallel with or downstream of the JAK-STAT pathway
  • contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • specifically interacts with estrogen receptor alpha ESR1 (at the TFF1 promoter, estrogen increases HMGN1 association through recruitment by ESR1)
  • HMGN1 is a new PCNA-interacting protein that enhances the binding of PCNA to chromatin but not to purified DNA
  • regulatory role for HMGN1 in PARP1 activation
  • HMGN1 modulates nucleosome occupancy and DNASE1 hypersensitivity at the CpG island promoters of embryonic stem cells 6)
  • is a potent alarmin that binds TLR4 and induces antigen-specific Th1 immune responses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS