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FLASH GENE
Symbol HLA-A contributors: mct/npt - updated : 18-08-2009
HGNC name major histocompatibility complex, class I, A
HGNC id 4931
Location 6p21.33      Physical location : 1.150.159 - 29.913.660
Synonym name
  • HLA-A,alpha chain,44kDa,class Ia
  • antigen presenting molecule
  • leukocyte antigen class I-A
  • MHC class I antigen HLA-A heavy chain
    • Synonym symbol(s) HLAA
    DNA
    TYPE functioning gene
    STRUCTURE 3.33 kb     8 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1538 38.2 365 - Krangel (1979)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three globular extracellular domains
  • alpha 1 and alpha 2 forming the peptide binding groove and a I,C-like alpha 3 domain
  • a single transmembrane domain
  • a cytoplasmic tail
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • presenting short pathogen-derived peptide to T cells initiating the adaptative, then immune response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimer with beta 2 microglobular (B2M)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding for adequate complexion
  • loaded by TAP molecules
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nasopharyngeal carcinoma
    Variant & Polymorphism other HLA-A*0207 increasing the risk of nasopharyngeal carcinoma (Tse 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS