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FLASH GENE
Symbol HLA-A contributors: mct/npt - updated : 18-08-2009
HGNC name major histocompatibility complex, class I, A
HGNC id 4931
Location 6p21.33      Physical location : 1.150.159 - 29.913.660
Synonym name
  • HLA-A,alpha chain,44kDa,class Ia
  • antigen presenting molecule
  • leukocyte antigen class I-A
  • MHC class I antigen HLA-A heavy chain
  • Synonym symbol(s) HLAA
    DNA
    TYPE functioning gene
    STRUCTURE 3.33 kb     8 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    Physical map
    HCGIV-08 HLA-G 6p21.3 HLA-G histocompatibility antigen, class I, G P5-11 6p21.3 P5-1 pseudogene HCGVIII-2 6p21.3 HCGVIII-2 pseudogene MICF 6p21.3 MHC class I polypeptide-related sequence F pseudogene 3.8-1.4 6p21.3 3.8-1.4 pseudogene P5-10 HCGIV-07 P5-09 6p21.3 P5-1 pseudogene HLA-H 6p21.3 major histocompatibility complex, class I, H (pseudogene) P5-07 6p21.3 P5-1 pseudogene HLA-16 6p21.3 HLA-16 pseudogene HCGII-7 3.8-1.3 6p21.3 3.8-1.3 pseudogene P5-06 HCGIV-6 P5-05 6p21.3 P5-1 pseudogene HLA-K 6p21.3 major histocompatibility complex, class I, K HLA-21 6p21.3 HLA-21 pseudogene P5.8 6p21.3 P5-1 pseudogene HCGIV-05 HLA-A 6p21.3 major histocompatibility complex, class I, A P5-03 HCGIV-04 HLA-80 6p21.3 HLA-80 pseudogene HCGII-6 MICD 6p21.3 MHC class I polypeptide-related sequence D HCGIX 3.8-1.2 6p21.3 3.8-1.2 pseudogene P5-02 HLA-J 6p21.3 major histocompatibility complex, class I, J (pseudogene)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1538 38.2 365 - Krangel (1979)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three globular extracellular domains
  • alpha 1 and alpha 2 forming the peptide binding groove and a I,C-like alpha 3 domain
  • a single transmembrane domain
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • presenting short pathogen-derived peptide to T cells initiating the adaptative, then immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimer with beta 2 microglobular (B2M)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding for adequate complexion
  • loaded by TAP molecules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nasopharyngeal carcinoma
    Variant & Polymorphism other HLA-A*0207 increasing the risk of nasopharyngeal carcinoma (Tse 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS