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FLASH GENE
Symbol HLA-A contributors: mct/npt - updated : 18-08-2009
HGNC name major histocompatibility complex, class I, A
HGNC id 4931
DNA
TYPE functioning gene
STRUCTURE 3.33 kb     8 Exon(s)
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1538 38.2 365 - Krangel (1979)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three globular extracellular domains
  • alpha 1 and alpha 2 forming the peptide binding groove and a I,C-like alpha 3 domain
  • a single transmembrane domain
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • presenting short pathogen-derived peptide to T cells initiating the adaptative, then immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimer with beta 2 microglobular (B2M)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding for adequate complexion
  • loaded by TAP molecules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nasopharyngeal carcinoma
    Variant & Polymorphism other HLA-A*0207 increasing the risk of nasopharyngeal carcinoma (Tse 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS