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FLASH GENE
Symbol HIST1H1B contributors: npt - updated : 20/11/2008
HGNC name histone cluster 1, H1b
HGNC id 4719
Location 6p21.3      Physical location : 27.834.570 - 27.835.359
Synonym name
  • linker histone 1,subtype 5
  • H1 histone family, member 5
  • histone 1, H1b
    • Synonym symbol(s) H1, H1.5, H1F5, MGC126630, MGC126632
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 0.86 kb     1 Exon(s)    1 Copie(s)
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure highly conserved H1/AC box
    MAPPING cloned Y linked N status confirmed
    regionally located in the small histone gene cluster
    RNA
    TRANSCRIPTS type messenger
    text lacking the polyA tail but having instead a palindromic termination element
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 790 22.5 226 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine
    • HOMOLOGY
    interspecies ortholog to murine Hist1h1b
    Homologene
    FAMILY
  • histone H1/H5 family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a key regulatory element of MYOD
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS