basic FUNCTION
| involved in attenuation of hedgehog signaling |
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is a surface receptor antagonist that is equipotent against all three mammalian Hh homologs |
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negative regulator of the sonic hedgehog pathway |
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essential role for ligand-dependent feedback inhibition of vertebrate HH signaling governed collectively by PTCH1, PTCH2 and HHIP |
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HHIP non-cell-autonomously inhibits HH-dependent neural progenitor patterning and proliferation |
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secreted activity of HHIP represents a novel mechanism to regulate HH ligand localization and function during embryogenesis |