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FLASH GENE

Symbol

HHIP

contributors: mct - updated : 11-10-2016

HGNC name	hedgehog interacting protein
HGNC id	14866

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in autoimmune hepatitis tumoral     --low   in most medulloblastoma cell lines

Susceptibility

to variation of lung function in subjects with chronic obstructive pulmonary disease (COPD) to combined pituitary hormone deficiency (CPHD)

Variant & Polymorphism SNP , other	genetic variants in HHIP are associated with lung function in subjects with COPD
	SNP in two Hedgehog genes, SHH and HHIP, are genetic cause of combined pituitary hormone deficiency

Candidate gene
Marker	expression of HHIP could be considered as significant prognostic marker for patients with glioblastoma (GBM)
Therapy target

ANIMAL & CELL MODELS