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FLASH GENE
Symbol HGF contributors: mct/npt - updated : 10-05-2017
HGNC name hepatocyte growth factor (hepatopoietin A; scatter factor)
HGNC id 4893
Corresponding disease
DFNB39 neurosensory deafness 39
Location 7q21.11      Physical location : 81.331.444 - 81.399.452
Synonym name
  • lung fibroblast-derived mitogen
  • fibroblast-derived tumor cytotoxic factor
  • hepatopoietin A
  • scatter factor
  • lung fibroblast-derived mitogen
  • Synonym symbol(s) SF, HPTA, F-TCF, HGFB
    DNA
    TYPE functioning gene
    STRUCTURE 68.01 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392063 7 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) LOC370523 7q11.23 similar to deltex 2 LOC389526 7 hypothetical gene supported by AK024602 LOC389527 7 similar to PMS4 homolog mismatch repair protein - human LOC202802 7q11.23 similar to Williams Beuren syndrome chromosome region 19 FGL2 7q11.2 fibrinogen-like 2 LOC54103 7q21.11 hypothetical protein LOC54103 LOC392064 7 similar to hypothetical protein LOC392065 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 LOC389528 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 AIP1 7q11.2 putative homeodomain transcription factor 2 LOC389529 7 LOC389529 LOC392066 7 similar to 60S ribosomal protein L10 (QM protein homolog) GNAI1 7q21.3-q22.1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 LOC346562 CD36 7q11.2 CD36 antigen (collagen type I receptor, thrombospondin receptor) SEMA3C 7q21-q31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C HGF 7q21.1 hepatocyte growth factor (hepatopoietin A; scatter factor) CACNA2D1 7q21.3-q22.1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 PCLO 7q11.23-q21.3 piccolo (presynaptic cytomatrix protein) LOC389530 7 similar to [Segment 1 of 2] Piccolo protein (Aczonin) SEMA3E 7q21.11-q31.33 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E SEMA3A 2q37-qter sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A HMG17P1 7q11-q21 high-mobility group (nonhistone chromosomal) protein 17 pseudogene 1 LOC285984 7q21.12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) SEMA3D 7q21.12 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D LOC392067 7 similar to dynein, cytoplasmic, light peptide GRM3 7q21.1-q21.2 glutamate receptor, metabotropic 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 2820 83 728 - Watanabe, Schultz (2009)
  • lacking exon 8
  • containing exon 5b (medium exon)
  • encoding for the longest product
  • propeptide maturing in an alpha and a bÍta chain
  • product having a "Pan_Apple", a "Tryp_SPc" and four "KR" domains
  • 8 splicing 1307 33 290 - Watanabe, Schultz (2009)
  • lacking exons 9 to 19
  • containing exon 5b (medium exon)
  • encoding for a product having a "Pan_Apple" and a "KR" domain
  • 18 splicing 2805 73 723 - Watanabe, Schultz (2009)
  • lacking exon 8
  • containing exon 5c (shorter than 5a & 5b)
  • product having a "Pan_Apple", a "Tryp_SPc" and four "KR" domains
  • 8 splicing 1292 23 285 - Watanabe, Schultz (2009)
  • lacking exons 9 to 19
  • containing exon 5c (shorter than 5a & 5b)
  • product having a "Pan_Apple" and two "KR" domains
  • 5 splicing 2079 24 210 - Watanabe, Schultz (2009)
  • lacking exon 6 to 19
  • containing exon 5a (longer than 5b & 5c)
  • encoding for the shortest product
  • product having a "Pan_Apple" and a "KR" domain
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  moderately
     liver   moderately
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   moderately
     thymus   lowly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   lowly
     respiratory tracttrachea  moderately
    Urinarykidney   lowly
    Visualeyeretina  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connective    
    Muscularsmooth  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    Digestivehepatocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text tissue at a lowly level
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide (3,5 kDa)
  • alpha and bÍta chains mature peptide liked by a disulfide bound
  • a Pan/Apple domain (Pan_Apple)
  • four cysteine-rich kringle domains (KR)
  • a trypsin-like serine protease domain (Tryp_SPc)
  • secondary structure pyrrolidone carboxylic acid (post translationally modified by the cyclization of a N-terminal glutamine)
    conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor a 697 amino acids propetide (79,6 kda)
    HOMOLOGY
    interspecies homolog to rattus Hgf (90,62 pc)
    homolog to murine Hgf (90,76 pc)
    Homologene
    FAMILY
  • peptidase family S1
  • plasminogen subfamily
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • required for normal embryonic development
  • being a potent mitogen for mature parenchymal hepatocyte cells
  • being an hepatotrophic factor
  • acting as growth factor for a broad spectrum of tissues and cell types
  • inducing Retinal Vascular Permeability (RVP) via MAP-Kinase and PI-3 Kinase without altering retinal hemodynamics
  • plays a critical role in differentiation of hepatic stem cells
  • implicated in branching morphogenesis and invasion, tumorigenesis, erythroid differentiation, neuronal survival, and wound healing (Schultz 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • axon guidance
  • embryogenesis and morphogenesis
  • control of cell proliferation
  • PATHWAY
    metabolism
    signaling
    a component
  • dimer of an alpha chain and a beta chain linked by a disulfide bond
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with SOCS3 (regulating HGF-induced keratinocyte migration by inhibiting STAT3 phosphorylation)
  • interacting with PRDM16 (in the central nervous system, appears to promote neural stem/progenitor cell function, partly by promoting HGF expression)
  • HGF prevents XDH activation following hypoxia/reoxygenation (H/R) primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Ca2+
  • cell & other
    REGULATION
    repressed by anti-tumor agent valproic acid (VPA), a histone deacetylase (HDAC) inhibitor
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB39
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hypopharyngeal squamous cell carcinoma
    tumoral     --over  
    with IL11, in polycythemia vera (PV)
    Susceptibility
    Variant & Polymorphism SNP HGF is a potential locus associated with high myopia in the Han Chinese population
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    blocking the MET/HGF/IL11 pathways could be of interest as an additional therapeutic option in polycythemia vera
    ANIMAL & CELL MODELS