being a potent mitogen for mature parenchymal hepatocyte cells
being an hepatotrophic factor
acting as growth factor for a broad spectrum of tissues and cell types
inducing Retinal Vascular Permeability (RVP) via MAP-Kinase and PI-3 Kinase without altering retinal hemodynamics
plays a critical role in differentiation of hepatic stem cells
implicated in branching morphogenesis and invasion, tumorigenesis, erythroid differentiation, neuronal survival, and wound healing (Schultz 2009)
CELLULAR PROCESS
cell life, proliferation/growth
cell communication
cell migration & motility
PHYSIOLOGICAL PROCESS
development
, nervous system
text
axon guidance
embryogenesis and morphogenesis
control of cell proliferation
PATHWAY
metabolism
signaling
a component
dimer of an alpha chain and a beta chain linked by a disulfide bond
INTERACTION
DNA
RNA
small molecule
protein
with SOCS3 (regulating HGF-induced keratinocyte migration by inhibiting STAT3 phosphorylation)
interacting with PRDM16 (in the central nervous system, appears to promote neural stem/progenitor cell function, partly by promoting HGF expression)
HGF prevents XDH activation following hypoxia/reoxygenation (H/R) primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Ca2+
cell & other
REGULATION
repressed by
anti-tumor agent valproic acid (VPA), a histone deacetylase (HDAC) inhibitor