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FLASH GENE
Symbol HGF contributors: mct/npt - updated : 10-05-2017
HGNC name hepatocyte growth factor (hepatopoietin A; scatter factor)
HGNC id 4893
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide (3,5 kDa)
  • alpha and bêta chains mature peptide liked by a disulfide bound
  • a Pan/Apple domain (Pan_Apple)
  • four cysteine-rich kringle domains (KR)
  • a trypsin-like serine protease domain (Tryp_SPc)
  • secondary structure pyrrolidone carboxylic acid (post translationally modified by the cyclization of a N-terminal glutamine)
    conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor a 697 amino acids propetide (79,6 kda)
    HOMOLOGY
    interspecies homolog to rattus Hgf (90,62 pc)
    homolog to murine Hgf (90,76 pc)
    Homologene
    FAMILY
  • peptidase family S1
  • plasminogen subfamily
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • required for normal embryonic development
  • being a potent mitogen for mature parenchymal hepatocyte cells
  • being an hepatotrophic factor
  • acting as growth factor for a broad spectrum of tissues and cell types
  • inducing Retinal Vascular Permeability (RVP) via MAP-Kinase and PI-3 Kinase without altering retinal hemodynamics
  • plays a critical role in differentiation of hepatic stem cells
  • implicated in branching morphogenesis and invasion, tumorigenesis, erythroid differentiation, neuronal survival, and wound healing (Schultz 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • axon guidance
  • embryogenesis and morphogenesis
  • control of cell proliferation
  • PATHWAY
    metabolism
    signaling
    a component
  • dimer of an alpha chain and a beta chain linked by a disulfide bond
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with SOCS3 (regulating HGF-induced keratinocyte migration by inhibiting STAT3 phosphorylation)
  • interacting with PRDM16 (in the central nervous system, appears to promote neural stem/progenitor cell function, partly by promoting HGF expression)
  • HGF prevents XDH activation following hypoxia/reoxygenation (H/R) primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Ca2+
  • cell & other
    REGULATION
    repressed by anti-tumor agent valproic acid (VPA), a histone deacetylase (HDAC) inhibitor
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB39
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hypopharyngeal squamous cell carcinoma
    tumoral     --over  
    with IL11, in polycythemia vera (PV)
    Susceptibility
    Variant & Polymorphism SNP HGF is a potential locus associated with high myopia in the Han Chinese population
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    blocking the MET/HGF/IL11 pathways could be of interest as an additional therapeutic option in polycythemia vera
    ANIMAL & CELL MODELS