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FLASH GENE
Symbol HERC1 contributors: mct - updated : 06-02-2008
HGNC name hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
HGNC id 4867
Location 15q22      Physical location : 63.900.817 - 64.126.147
Synonym name
  • guanine nucleotide exchange factor p532
  • hect domain and RCC1-like domain 1
  • Synonym symbol(s) P532, H6, GEF, p619
    DNA
    TYPE functioning gene
    STRUCTURE 226.00 kb     77 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388125 15 similar to hypothetical LOC237397 FLJ38723 15q21.3 hypothetical protein FLJ38723 TLN2 15q15-q21 talin 2 LOC390592 15 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 TPM1 15q22.1 tropomyosin 1 (alpha) LACTB 15q22.1 lactamase, beta RPS27L 15q21.3 ribosomal protein S27-like LOC51762 PSFL 15q22.1 anterior pharynx defective 1B-like LOC388126 15 LOC388126 FLJ20151 15q22.1 hypothetical protein FLJ20151 CA12 15q22 carbonic anhydrase XII USP3 15q22.3 ubiquitin specific protease 3 LOC390593 15 similar to RIKEN cDNA 1110004B15 HERC1 15q22 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 DAPK2 15q22.1 death-associated protein kinase 2 FLJ22875 15q22.1 hypothetical protein FLJ22875 SNX1 15q22-q23 sorting nexin 1 SNX22 20q12-13.1 sorting nexin 22 PPIB 15q21-q22 peptidylprolyl isomerase B (cyclophilin B) CSNK1G1 15q22.1-q22.31 casein kinase 1, gamma 1 KIAA0101 15q22.1 casein kinase 1, gamma 1 TRIP4 15q22.1 thyroid hormone receptor interactor 4 KIAA0295 15q21.3-q22.1 thyroid hormone receptor interactor 4 OAZ2 15q22 ornithine decarboxylase antizyme 2 RBPMS2 15q22.1 RNA-binding protein with multiple splicing 2 FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094 MtFMT 15q22.2 methionyl-tRNA formyltransferase, mitochondrial OSTbeta 15q22.2 organic solute transporter beta RIS LOC390594 15 similar to RIKEN cDNA C230080I20 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    77 - 15216 - 4861 - Garcia-Gonzalo (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two regions of seven internal RLD repeats beta-repeat domains characteristic of the beta-subunit of heterotrimeric G proteins
  • one WD40 domain
  • three putative SH3 binding sites, seven polar amino acid-rich regions, a RCC1 domain
  • a putative leucine zipper
  • a C terminal HECT domain characteristic of E3 ubiquitin ligases
  • HOMOLOGY
    intraspecies homolog to HECT (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD)1
    Homologene
    FAMILY HERC family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in protein trafficking
  • stimulating guanine nucleotide exchange on ARF1 and Rab proteins
  • regulating cell growth through inhibition of the mammalian target of rapamycin pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a cytosolic ternary complex with clathrin and Hsp70, involved in protein trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • myristoylated ARF1 (small GTP binding protein)
  • clathrin, heavy chain, only on the cytosol
  • TSC2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS