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FLASH GENE
Symbol HERC1 contributors: mct - updated : 06-02-2008
HGNC name hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
HGNC id 4867
DNA
TYPE functioning gene
STRUCTURE 226.00 kb     77 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
77 - 15216 - 4861 - Garcia-Gonzalo (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Nervousnerve   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two regions of seven internal RLD repeats beta-repeat domains characteristic of the beta-subunit of heterotrimeric G proteins
  • one WD40 domain
  • three putative SH3 binding sites, seven polar amino acid-rich regions, a RCC1 domain
  • a putative leucine zipper
  • a C terminal HECT domain characteristic of E3 ubiquitin ligases
  • HOMOLOGY
    intraspecies homolog to HECT (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD)1
    Homologene
    FAMILY HERC family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in protein trafficking
  • stimulating guanine nucleotide exchange on ARF1 and Rab proteins
  • regulating cell growth through inhibition of the mammalian target of rapamycin pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a cytosolic ternary complex with clathrin and Hsp70, involved in protein trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • myristoylated ARF1 (small GTP binding protein)
  • clathrin, heavy chain, only on the cytosol
  • TSC2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS