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FLASH GENE

Symbol

HECA

contributors: - updated : 09-02-2006

HGNC name	headcase homolog (Drosophila)
HGNC id	21041

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q23-q24      Physical location : 139.456.248 - 139.501.945
Synonym symbol(s)	HDCL, hHDC, HDC, dJ225E12.1

DNA

TYPE	functioning gene
STRUCTURE	45.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   ALU
text structure	an ALU repeat in the 3'UTR region, in the opposite strand of the last exon

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Cardiovascular heart       highly Endocrine pancreas       lowly Urinary kidney       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to chimpanzee heca
	ortholog to murine Heca

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	cell differentiation regulator
	may play an important role in some human cancers
	may be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development , electron transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     commonly, in pancreatic cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS