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FLASH GENE
Symbol HECA contributors: - updated : 09-02-2006
HGNC name headcase homolog (Drosophila)
HGNC id 21041
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
text structure an ALU repeat in the 3'UTR region, in the opposite strand of the last exon
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Cardiovascularheart   highly
Endocrinepancreas   lowly
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to chimpanzee heca
ortholog to murine Heca
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • cell differentiation regulator
  • may play an important role in some human cancers
  • may be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    commonly, in pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS