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FLASH GENE
Symbol HCRT contributors: mct - updated : 06-07-2011
HGNC name hypocretin (orexin) neuropeptide precursor
HGNC id 4847
Location 17q21      Physical location : 40.336.077 - 40.337.470
Synonym name orexin A and B
Synonym symbol(s) OX, PPOX, NRCLP1
DNA
TYPE functioning gene
STRUCTURE 1.30 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
MGC20781 17q21.31 hypothetical protein MGC20781 KLHL10 17q21.2 kelch-like 10 (Drosophila) FLJ10572 17q21.31 hypothetical protein FLJ10572 ACLY 17q21-q22 ATP citrate lyase DKFZP434H0115 17q21.31 hypothetical protein DKFZp434H0115 CNP 17q21 2',3'-cyclic nucleotide 3' phosphodiesterase DNAJC7 17q11.2 DnaJ (Hsp40) homolog, subfamily C, member 7 KBRAS2 17q21.31 I-kappa-B-interacting Ras-like protein 2 LOC201181 17q21.31 similar to hypothetical protein A930006D11 LOC390796 17 similar to hypothetical protein A930006D11 LGP2 17q21.2 similar to hypothetical protein A930006D11 GCN5L2 17q21 GCN5 general control of amino-acid synthesis 5-like 2 (yeast) HspB9 17q21.31 small heat shock protein B9 RAB5C 17q21 RAB5C, member RAS oncogene family KCNH4 17q21.31 potassium voltage-gated channel, subfamily H (eag-related), member 4 HCRT 17q21 hypocretin (orexin) neuropeptide precursor LGP1 17q21.2 hypocretin (orexin) neuropeptide precursor STAT5B 17q11.2 signal transducer and activator of transcription 5B STAT5A 17q11.2 signal transducer and activator of transcription 5A MGC16063 17q21.31 hypothetical protein MGC16063 STAT3 17q21 signal transducer and activator of transcription 3 (acute-phase response factor) PTRF 17q21.2 polymerase I and transcript release factor ATP6V0A1 17q21.3 ATPase, H+ transporting, lysosomal V0 subunit a isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 577 - 131 - 1998 9419374
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Endocrineadrenal gland    
 pancreas    
Nervousbraindiencephalonhypothalamus highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal myenteric plexuses, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
neuropeptide precursor of isoforms A and B
HOMOLOGY
intraspecies homolog to secretin
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text synaptic vesicles
basic FUNCTION
  • potential mediator in the central feedback mechanism, that regulates feeding behavior
  • hypothalamic neuropeptide precusor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing
  • regulating feeding and sleeping
  • involvement of hypocretin in sleep disorders in dementia with Lewy bodies
  • are critical for the normal temporal structure of sleep and wakefulness, they also appear to be important in regulating baseline blood pressure and possibly in modulating the effects of sleep on blood pressure
  • potently influences dopamine neuron activity, in part by modulating responses to medial prefrontal cortex inputs
  • hypothalamic polypeptides such as PMCH and HCRT are promoters of sleep-wake regulation and energy homeostasis and are found to impact on cognitive performance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component component of hypocretin system, involved primarily in the circadian timing of sleep and wakefulness but also in the control of other biological functions such as thermoregulation
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC17A7, SLC17A6(many of the orexin neurons are glutamatergic)
  • activates the hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor whose pathogenic role in stimulating angiogenesis in hypoxic tumors has been the focus of intense investigation
  • IGFBP3 is a new regulator of hypocretin cell physiology that may be involved not only in the pathophysiology of narcolepsy, but also in the regulation of sleep in normal individuals, most notably during adolescence
  • interacting with NR6A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    number of hypocretin neurons is significantly reduced in patients with severe traumatic brain injury
    Susceptibility susceptibility gene for narcolepsy
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS