Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HCRT contributors: mct - updated : 06-07-2011
HGNC name hypocretin (orexin) neuropeptide precursor
HGNC id 4847
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
neuropeptide precursor of isoforms A and B
HOMOLOGY
intraspecies homolog to secretin
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text synaptic vesicles
basic FUNCTION
  • potential mediator in the central feedback mechanism, that regulates feeding behavior
  • hypothalamic neuropeptide precusor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing
  • regulating feeding and sleeping
  • involvement of hypocretin in sleep disorders in dementia with Lewy bodies
  • are critical for the normal temporal structure of sleep and wakefulness, they also appear to be important in regulating baseline blood pressure and possibly in modulating the effects of sleep on blood pressure
  • potently influences dopamine neuron activity, in part by modulating responses to medial prefrontal cortex inputs
  • hypothalamic polypeptides such as PMCH and HCRT are promoters of sleep-wake regulation and energy homeostasis and are found to impact on cognitive performance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component component of hypocretin system, involved primarily in the circadian timing of sleep and wakefulness but also in the control of other biological functions such as thermoregulation
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC17A7, SLC17A6(many of the orexin neurons are glutamatergic)
  • activates the hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor whose pathogenic role in stimulating angiogenesis in hypoxic tumors has been the focus of intense investigation
  • IGFBP3 is a new regulator of hypocretin cell physiology that may be involved not only in the pathophysiology of narcolepsy, but also in the regulation of sleep in normal individuals, most notably during adolescence
  • interacting with NR6A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    number of hypocretin neurons is significantly reduced in patients with severe traumatic brain injury
    Susceptibility susceptibility gene for narcolepsy
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS