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FLASH GENE

Symbol

GSTM1

contributors: mct/pgu - updated : 29-05-2017

HGNC name	glutathione S-transferase M1
HGNC id	4632

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p13.3      Physical location : 110.230.417 - 110.236.366
Synonym name	GST HB subunit 4
	GST class-mu 1
	HB subunit 4
	S-(hydroxyalkyl)glutathione lyase
	glutathione S-alkyltransferase
	glutathione S-aralkyltransferase
	glutathione S-aryltransferase
	glutathione S-transferase M1
	glutathione S-transferase Mu 1
Synonym symbol(s)	MU, GST1, HB, GTM1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, H-B, MGC26563, MU-1
EC.number	2.5.1.18

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	5.95 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

two alleles GSTM1a and GSTM1b differing in position 172

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D1S2792 - D1S2651 - GSTM1 - D1S221 - D1S2695 - cen
Authors	Xu (98)

regionally located

genes spacing approximately 20 kb apart

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000561 8 - 1266 NP_000552 - 218 - 2007 17880378 NM_146421 7 - 1155 NP_666533 - 181 - 2007 17880378

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus       highly   stomach         Nervous nerve       highly Reproductive female system breast mammary gland   highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to Gstm1, Mus musculus
	ortholog to Gstm1, Rattus norvegicus
	ortholog to GSTM1, Pan troglodytes

Homologene

FAMILY	GST superfamily
	mu family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	conjugating reduced glutathione to a wide mumber of exogenous and endogenous hydrophobic electrophiles
	playing a role in telomere attrition and subsequent telomerase activity in the cancer cells
	absence of GSTM1 activity can be compensated for by the overexpression of GSTM2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

metabolism of a broad range of xenobiotics and carcinogens

a component

INTERACTION

DNA

RNA

small molecule

protein

modifier of the GSTP1 gene in childhood asthma

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease tumoral     --low   significantly associated with favorable prognosis in Colon adenocarcinoma (COAD)

Susceptibility

to endometrial cancer to age-related hearing impairment to acute lymphoid and myeloid leukemia to vitiligo to head and neck cancer predisposition for developing leukopenia to lung cancer patients by tobacco smokers to non-Hodgkin lymphoma (NHL) to idiopathic male infertility to type-2 diabetes

Variant & Polymorphism other	idiopathic Parkinson's disease
	null variants increasing the risk of acute lymphoid and myeloid leukemia
	GSTM1 null type might be associated with vitiligo
	GSTM1-null genotype associated with head and neck cancer
	significant risk for lung cancer concerning tobacco smoking was found in the association of null genotypes for GSTM1 and GSTT1
	rs1695 AG and the combined AG/GG genotypes were associated with decreased risk of NHL
	null genotypes (GSTT1 and GSTM1) are a potential biomarker of predisposition for developing leukopenia
	increased risk of GSTM1 or GSTT1 null genotypes for developing male infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors
	GSTM1 null genotypes are associated with increased risk for senile cataract in Asian populations but not in Caucasian populations (

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS