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FLASH GENE
Symbol GSTM1 contributors: mct/pgu - updated : 29-05-2014
HGNC name glutathione S-transferase M1
HGNC id 4632
Location 1p13.3      Physical location : 110.230.417 - 110.236.366
Synonym name
  • GST HB subunit 4
  • GST class-mu 1
  • HB subunit 4
  • S-(hydroxyalkyl)glutathione lyase
  • glutathione S-alkyltransferase
  • glutathione S-aralkyltransferase
  • glutathione S-aryltransferase
  • glutathione S-transferase M1
  • glutathione S-transferase Mu 1
  • Synonym symbol(s) MU, GST1, HB, GTM1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, H-B, MGC26563, MU-1
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.95 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure two alleles GSTM1a and GSTM1b differing in position 172
    MAPPING cloned Y linked   status confirmed
    Map pter - D1S2792 - D1S2651 - GSTM1 - D1S221 - D1S2695 - cen
    Authors Xu (98)
    Physical map
    KIAA0893 1p13.3 LOC388663 NDUFB3P1 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1 AD-020 1p13.3 protein x 013 LOC391065 1 similar to poly(rC) binding protein 1; heterogenous nuclear ribonucleoprotein X; poly(rC)-binding protein 1; alpha-CP1; nucleic acid binding protein sub 2.3; heterogenous nuclear ribonucleoprotein E1 LOC127003 1p13.3 similar to CG5435-PA KIAA1324 1p13.2 maba1 SARS 1p13 seryl-tRNA synthetase CELSR2 1p21.16p13.3 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) DDA3 1p13.2 differential display and activated by p53 LOC343263 1p13.2 similar to Myosin-binding protein H (MyBP-H) (H-protein) SORT1 1p21.3-p13.1 Sortilin 1 PSMA5 1p13 proteasome (prosome, macropain) subunit, alpha type, 5 LOC388660 1 similar to mitsugumin29 LOC284612 1p13.2 hypothetical protein LOC284612 MGC46534 1p13.2 hypothetical protein MGC46534 FLJ39035 1p13.2 hypothetical protein FLJ39035 KIAA1163 1p13.2 amphoterin-induced gene GPR61 1p13.1 G protein-coupled receptor 61 GNAI3 1p13 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAT2 1p13 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 AMPD2 1p21-p13 adenosine monophosphate deaminase 2 (isoform L) GSTM4 1p13.3 glutathione S-transferase M4 GSTM2 1p13.3 glutathione S-transferase M2 (muscle) GSTM1 1p13.3 glutathione S-transferase M1 GSTM5 1p13.3 glutathione S-transferase M5 GSTM3 1p13.3 glutathione S-transferase M3 (brain) EPS8L3 1p13.2-p11 EPS8-like 3 CSF1 1p21-p13.3 colony stimulating factor 1 (macrophage) AHCYL1 1p12 S-adenosylhomocysteine hydrolase-like 1 PRO0233 1p13.2 PRO0233 protein ALX3 1p23-p21 aristaless-like homeobox 3 LOC164153 1p13.2 similar to RIKEN cDNA 4930522D07 LOC388661 1 LOC388661 LOC388662 1 similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 KCNC4 1p21 potassium voltage-gated channel, Shaw-related subfamily, member 4 LOC388663 1 LOC388663
    regionally located genes spacing approximately 20 kb apart
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1266 - 218 - 2007 17880378
    7 - 1155 - 181 - 2007 17880378
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     stomach    
    Nervousnerve   highly
    Reproductivefemale systembreastmammary gland highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gstm1, Mus musculus
    ortholog to Gstm1, Rattus norvegicus
    ortholog to GSTM1, Pan troglodytes
    Homologene
    FAMILY
  • GST superfamily
  • mu family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • conjugating reduced glutathione to a wide mumber of exogenous and endogenous hydrophobic electrophiles
  • playing a role in telomere attrition and subsequent telomerase activity in the cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    metabolism of a broad range of xenobiotics and carcinogens
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein modifier of the GSTP1 gene in childhood asthma
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease
    Susceptibility
  • to endometrial cancer
  • to age-related hearing impairment
  • to acute lymphoid and myeloid leukemia
  • to vitiligo
  • to head and neck cancer
  • predisposition for developing leukopenia
  • to lung cancer patients by tobacco smokers
  • to non-Hodgkin lymphoma (NHL)
  • to idiopathic male infertility
  • to type-2 diabetes
  • Variant & Polymorphism other
  • idiopathic Parkinson's disease
  • null variants increasing the risk of acute lymphoid and myeloid leukemia
  • GSTM1 null type might be associated with vitiligo
  • GSTM1-null genotype associated with head and neck cancer
  • significant risk for lung cancer concerning tobacco smoking was found in the association of null genotypes for GSTM1 and GSTT1
  • rs1695 AG and the combined AG/GG genotypes were associated with decreased risk of NHL
  • null genotypes (GSTT1 and GSTM1) are a potential biomarker of predisposition for developing leukopenia
  • increased risk of GSTM1 or GSTT1 null genotypes for developing male infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors
  • GSTM1 null genotypes are associated with increased risk for senile cataract in Asian populations but not in Caucasian populations (
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS