basic FUNCTION
| playing a central role in verbal memory and cognitive function |
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playing a key role in the plasticity of synapses |
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and in excitatory neurostransmission |
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ligand-gated ion channel (Ca2+) transporting, when bound to glutamate and Mg2+ released |
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playing a central role in the striatum, in long potentiation memory, motor learning and cognitive function |
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playinga role in controlling T cell activation |
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activates multiple kinases and changes the phosphorylation of many postsynaptic proteins organized in signaling networks |
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its activation induces postnatal Müller glia-derived retinal cell progenitor proliferation and transcription factor CREB phosphorylation (activation induces postnatal Müller glia-derived retinal cell progenitor proliferation and transcription factor CREB phosphorylation) |
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by tethering Galpha with mu-opioid receptor (OPM1), GRIN1 stabilizes the receptor within the lipid rafts and potentiates the receptor signaling in the neurite outgrowth processes |
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main component of functional N-methyl-d-aspartic acid receptors that are involved in the glucocorticoid-induced neuronal damage |
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activity of the GRIN1/GRIN2D NMDA receptor is controlled distinctively by the endogenous neurotransmitter L-glutamate |
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role in controlling the intrinsic excitability of primary sensory neurons possibly via Ca(2+)-activated slow conductance K(+) (SK) channels |
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primary motor cortex NMDA receptors are necessary for activity-dependent synaptic strengthening and associative learning |
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Schwann cell signaling receptor for protein ligands and a major regulator of Schwann cell physiology, which may be particularly important in peripheral nervous system (PNS) injury |