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FLASH GENE
Symbol GRIN1 contributors: mct - updated : 21-10-2016
HGNC name glutamate receptor, ionotropic, N-methyl D-aspartate 1
HGNC id 4584
ASSOCIATED DISORDERS
corresponding disease(s) MRD8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
significantly increased in male patients with AD
constitutional     --low  
decreased in postmortem brain from people with schizophrenia
Susceptibility
  • to schizophrenia
  • to infantile spasms responsive to to adrenocorticotropic hormone
  • Variant & Polymorphism other
  • polymorphism G1001C asssociated to allele T4197C and T5988C of GRIN2B increasing the risk of schizophrenia
  • in homozygous carriers of the CTA haplotype was higher responsive to adrenocorticotropic hormone than that in heterozygous carriers and non-carriers
  • Candidate gene torsion dystonia
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    a potential therapeutic target for preventing white matter damage in a variety of diseases
    obesity  
    dorsal vagal complex GRIN2A, GRIN1 can a potential therapeutic target for obesity
    diabete  
    dorsal vagal complex GRIN2A, GRIN1 can a potential therapeutic target for diabetes
    ANIMAL & CELL MODELS
  • CA1-specific Nmdar 1 knockout mice
  • GluN1 hypomorph mice exhibit wide-ranging behavioral alterations