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FLASH GENE
Symbol GPR35 contributors: mct/npt/shn/pgu - updated : 24-03-2011
HGNC name G protein-coupled receptor 35
HGNC id 4492
Corresponding disease
DEL2Q37 chromosome 2q subtelomeric deletion syndrome
Location 2q37.3      Physical location : 241.544.824 - 241.570.675
Synonym name
  • G-protein coupled receptor 35
  • KYNA receptor
  • kynurenic acid receptor
  • DNA
    TYPE functioning gene
    STRUCTURE 6.02 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S125 - D2S395 - GPR35 - D2S140 - D2S2585 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 1875 - 309 predominantly detected in immune cells and the gastrointestinal tract 2006 16754668
    2 splicing 2179 - 340 - 2006 16754668
    2 splicing 2293 - 340 - 2006 16754668
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     salivary gland   highly
     stomach    
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemovary   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage invariant natural killer T (iNKT) cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    interspecies ortholog to GPR35, GPR35
    ortholog to GPR35, Pan troglodytes
    ortholog to Gpr35, Mus musulus
    ortholog to Gpr35, Rattus norvegicus
    Homologene
    FAMILY
  • G protein-coupled receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • receptor having rhodopsin-like receptor activity
  • functions as a receptor for the kynurenine pathway intermediate kynurenic acid
  • having a potential role in regulating neuronal excitability and synaptic release
  • receptor for lysophosphatidic acid
  • play an important role in immune modulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    potential exploratory target for the treatment of both metabolic disorders and hypertension
    ANIMAL & CELL MODELS