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FLASH GENE
Symbol GPR26 contributors: mct - updated : 12-03-2019
HGNC name G protein-coupled receptor 26
HGNC id 4481
Location 10q26.13      Physical location : 125.425.870 - 125.456.911
Synonym symbol(s) MGC138216, DKFZp761H2121, FLJ33774
DNA
TYPE functioning gene
STRUCTURE 31.05 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU   long interspersed repetitive elements
MAPPING cloned Y linked N status provisional
Physical map
ATE1 10q26.13 arginyltransferase 1 FLJ20003 10q26.13 hypothetical protein FLJ20003 TACC2 10q26 transforming, acidic coiled-coil containing protein 2 FLJ25359 10q26.13 hypothetical protein FLJ25359 PLEKHA1 10q26.3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 LOC387715 10 LOC387715 PRSS11 10q25.3-q26.2 protease, serine, 11 (IGF binding) LOC253436 10q26.13 hypothetical LOC253436 LOC390008 10 similar to hensin CUZD1 10q26.13 CUB and zona pellucida-like domains 1 MGC45962 10q26.13 hypothetical protein MGC45962 LOC118670 10q26.13 similar to hypothetical protein MGC45962 FLJ13490 10q26.13 hypothetical protein FLJ13490 MGC35392 10q26.13 hypothetical protein MGC35392 PEGASUS 10q26 zinc finger protein, subfamily 1A, 5 (Pegasus) ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587 FLJ12616  hypothetical protein FLJ12616 LOC340735 10q26.2 similar to germ cell specific Y-box binding protein; contrin OAT 10q26 ornithine aminotransferase (gyrate atrophy) OATL3 10q26 ornithine aminotransferase-like 3 (pseudogene) LOC390010 10 similar to Sax-1 LHPP 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0140 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0157 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 10316 37.5 337 - 2002 11854302
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven predicted transmembrane domains
  • a short N terminus lacking the potential N-linked glycosylation site typical of other GPRs
  • a pair of cationic residues corresponding to cationic residues conserved in purinergic P2Y receptors
  • HOMOLOGY
    interspecies homolog to rattus GPR26
    intraspecies homolog to HTR5A
    homolog to BB2
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text exclusively in brain
    basic FUNCTION
  • activate G proteins in a manner that is distinct from other group 1 GPCRs
  • could be a suppressor of primary glioblastoma development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly less transcribed in glioblastoma tissues from older patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS