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FLASH GENE
Symbol GPR26 contributors: mct - updated : 12-03-2019
HGNC name G protein-coupled receptor 26
HGNC id 4481
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven predicted transmembrane domains
  • a short N terminus lacking the potential N-linked glycosylation site typical of other GPRs
  • a pair of cationic residues corresponding to cationic residues conserved in purinergic P2Y receptors
  • HOMOLOGY
    interspecies homolog to rattus GPR26
    intraspecies homolog to HTR5A
    homolog to BB2
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text exclusively in brain
    basic FUNCTION
  • activate G proteins in a manner that is distinct from other group 1 GPCRs
  • could be a suppressor of primary glioblastoma development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly less transcribed in glioblastoma tissues from older patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS