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FLASH GENE

Symbol

GPR25

contributors: mct - updated : 30-04-2020

HGNC name	G protein-coupled receptor 25
HGNC id	4480

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32.1      Physical location : 200.842.165 - 200.843.251

DNA

TYPE	functioning gene
STRUCTURE	1.19 kb     1 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005298 1 - 1198 NP_005289 - 361 - 1997 9020062

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

intraspecies

homolog to receptors involved in blood pressure regulation

Homologene

FAMILY

G protein coupled receptor 1 family

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

is an orphan G protein-coupled receptor in vertebrates, that has been implicated to be associated with autoimmune diseases and regulate blood pressure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

orphan receptor GPR25 possesses two potential ligands APLN and APELA and its activation decreases intracellular cAMP levels in non-mammalian vertebrates, but also facilitates to unravel the physiological roles of GPR25 signaling in vertebrates

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS