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FLASH GENE
Symbol GPR25 contributors: mct - updated : 30-04-2020
HGNC name G protein-coupled receptor 25
HGNC id 4480
Location 1q32.1      Physical location : 200.842.165 - 200.843.251
DNA
TYPE functioning gene
STRUCTURE 1.19 kb     1 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1198 - 361 - 1997 9020062
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
intraspecies homolog to receptors involved in blood pressure regulation
Homologene
FAMILY G protein coupled receptor 1 family
CATEGORY receptor G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • is an orphan G protein-coupled receptor in vertebrates, that has been implicated to be associated with autoimmune diseases and regulate blood pressure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • orphan receptor GPR25 possesses two potential ligands APLN and APELA and its activation decreases intracellular cAMP levels in non-mammalian vertebrates, but also facilitates to unravel the physiological roles of GPR25 signaling in vertebrates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS