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FLASH GENE
Symbol GPR12 contributors: mct/npt - updated : 01-10-2009
HGNC name G protein-coupled receptor 12
HGNC id 4466
Location 13q12.13      Physical location : 27.329.340 - 27.334.922
Synonym symbol(s) GPCR21, FLJ18149, FLJ97704, GPCR12, MGC138349, MGC138351
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin PABPC3 13q11-q12 poly(A) binding protein, cytoplasmic 3 FLJ25477 13q12.13 hypothetical protein FLJ25477 MTMR6 13q12 myotubularin related protein 6 NUPL1 13q12.12 nucleoporin like 1 LOC246717 13q12 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene ATP8A2 13q12-13 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 LOC387914 13 similar to WGAR9166 RNF6 13q12 ring finger protein (C3H2C3 type) 6 CDK8 13q12 cyclin-dependent kinase 8 WASF3 13q12 WAS protein family, member 3 LOC390389 13 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 GPR12 13q12 G protein-coupled receptor 12 USP12 5q33-q34 ubiquitin specific protease 12 RPL21 13pter-p13 ribosomal protein L21 LOC254109 13q12.2 similar to MGC53580 protein GTF3A 13q12.3-q13.1 general transcription factor IIIA MTIF3 13q12.2 mitochondrial translational initiation factor 3 PDZRN1 13q12.2 PDZ domain containing ring finger 1 MGC9850 13q12.2 hypothetical protein MGC9850 POLR1D 13q12.2 polymerase (RNA) 1 polypeptide D, 16kDa GSH1 13q12.13 GS homeobox 1 IPF1 13q12.1 insulin promoter factor 1, homeodomain transcription factor LOC387915 13 hypothetical gene supported by AK000246 CDX2 13q12-q13 caudal type homeo box transcription factor 2 FLT3 13q12 fms-related tyrosine kinase 3 LOC390390 13 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein LOC390391 13 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) PAN3 13q12.2 PABP1-dependent poly A-specific ribonuclease subunit PAN3 FLT1 13q12 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) LOC341784 13q12.3 similar to eukaryotic translation initiation factor 4A1; initiation factor eIF-4A long form C13orf12 13q12.13 chromosome 13 open reading frame 12 LOC283537 13q12.3 hypothetical protein LOC283537 CYP51P2 13 hypothetical protein LOC283537 KIAA0774 13q12.13-q12.2 hypothetical protein LOC283537
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4863 - 334 - Song (1995)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor having G protein coupled receptor activity
  • play roles in neuroinflammation (Bedard 2007)
  • up-regulates cAMP production in neurons, stimulates neurite outgrowth, and counteracts myelin inhibition (Tanaka 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene new selective markers for microglia, which should prove useful not only to identify and isolate these cells, but also to better understand their distinctive properties (Bedard 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS