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FLASH GENE
Symbol GPR12 contributors: mct/npt - updated : 01-10-2009
HGNC name G protein-coupled receptor 12
HGNC id 4466
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor having G protein coupled receptor activity
  • play roles in neuroinflammation (Bedard 2007)
  • up-regulates cAMP production in neurons, stimulates neurite outgrowth, and counteracts myelin inhibition (Tanaka 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene new selective markers for microglia, which should prove useful not only to identify and isolate these cells, but also to better understand their distinctive properties (Bedard 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS