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FLASH GENE

Symbol

GPD1

contributors: mct - updated : 25-01-2012

HGNC name	glycerol-3-phosphate dehydrogenase 1 (soluble)
HGNC id	4455

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TCHF transient childhood hypertriglyceridemia and fatty liver followed by hepatic fibrosis
Location	12q13.12      Physical location : 50.497.800 - 50.505.093
Synonym name	GPDH-C
	glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Synonym symbol(s)	G3P
EC.number	1.1.1.8

DNA

TYPE	functioning gene
STRUCTURE	7.29 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005276 8 - 2909 - 349 - 2006 16460752

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Homo sapiens Nervous brain         Homo sapiens Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains

secondary structure

secondary structure with various active sites in addition to a relatively conserved C terminal

HOMOLOGY

Homologene

FAMILY

NAD-dependent glycerol-3-phosphate dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic

basic FUNCTION	GRB14, GPD1, and MSTN are potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
	key enzyme that connects carbohydrate and lipid metabolism
	catalyzes the reversible redox reaction of dihydroxyacetone phosphate (DHAP) and nicotine adenine dinucleotide, reduced (NADH) to glycerol-3-phosphate (G3P) and nicotinamide adenine dinucleotide (NAD+)
	with GPD2, plays an important role in the transport of reducing equivalents from the cytosol to the mitochondria

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TCHF

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   contributing to the increase of triacylglycerol (TAG) synthesis in obese subjects

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS