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FLASH GENE
Symbol GPD1 contributors: mct - updated : 25-01-2012
HGNC name glycerol-3-phosphate dehydrogenase 1 (soluble)
HGNC id 4455
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2909 - 349 - 2006 16460752
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver     Homo sapiens
Nervousbrain     Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
secondary structure secondary structure with various active sites in addition to a relatively conserved C terminal
HOMOLOGY
Homologene
FAMILY
  • NAD-dependent glycerol-3-phosphate dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GRB14, GPD1, and MSTN are potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
  • key enzyme that connects carbohydrate and lipid metabolism
  • catalyzes the reversible redox reaction of dihydroxyacetone phosphate (DHAP) and nicotine adenine dinucleotide, reduced (NADH) to glycerol-3-phosphate (G3P) and nicotinamide adenine dinucleotide (NAD+)
  • with GPD2, plays an important role in the transport of reducing equivalents from the cytosol to the mitochondria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TCHF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributing to the increase of triacylglycerol (TAG) synthesis in obese subjects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS