Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPAA1 contributors: mct - updated : 11-09-2019
HGNC name glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
HGNC id 4446
Corresponding disease
GPIBD15 glycosylphosphatidylinositol biosynthesis defect 15
Location 8q24.3      Physical location : 145.137.523 - 145.141.118
Synonym name
  • anchor attachment protein 1 (Gaa1p, yeast) homolog
  • GPI transamidase subunit
  • GPAA1P anchor attachment protein 1 homolog (yeast)
  • GPAA1 protein homolog
  • Synonym symbol(s) GAA1, GPIBD15, hGAA1
    DNA
    TYPE functioning gene
    STRUCTURE 3.58 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC286075 8q24.3 hypothetical protein LOC286075 LOC286076 8q24.3 similar to hypothetical protein ERK8  extracellular signal-regulated kinase 8 FLJ46072 8q24.3 FLJ46072 protein LOC389695 8 LOC389695 LOC389696 8 LOC389696 LOC286080 8q24.3 similar to CG3104-PA SCRIB 8q24.3 similar to CG3104-PA SIAHBP1 8q24.2-qtel similar to CG3104-PA LOC340371 8q24.3 hypothetical protein LOC340371 LOC389697 8 similar to epiplakin LOC392274 8 similar to cDNA sequence BC024139 PLEC1 8q24 plectin 1, intermediate filament binding protein 500kDa FLJ14464 8q24.3 hypothetical protein FLJ14464 GRINA 8q24 glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) MGC61633 8q24.3 similar to Putative protein C21orf56 LOC392275 8 similar to sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) OPLAH 8q24 5-oxoprolinase (ATP-hydrolysing) RRP41 8q24.3 exosome complex exonuclease RRP41 GPAA1 8q24.3 GPAA1P anchor attachment protein 1 homolog (yeast) CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2058 67.5 621 - 2017 29100095
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    Homo sapiens
    Urinarykidney    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic N terminus and a large luminal loop between its first two transmembrane spans
  • a siggnal peptide
  • a GPI transamidase, component domain
  • two phosphorylation sites
  • two N-glysocylation sites
  • a leucine zipper motif
  • eight transmembrane segments (TM8)
  • HOMOLOGY
    interspecies homolog to yeast Gaa1p
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • likely is passively retained in the ER by a signalless mechanism
  • basic FUNCTION
  • glycosylphosphatidylinositol anchor attachment protein 1
  • is predicted to be the enzyme that catalyzes the attachment of the glycosylphosphatidyl (GPI) lipid anchor to the carbonyl intermediate of the substrate protein at the omega-site
  • is the subunit of the GPI transamidase that transfers the GPI anchor to proteins within the ER
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component putative component of GPItransamidase (see PIGK)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPIBD15
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in gastric cancer
    tumoral     --over  
    in patients with colorectal cancer, which indicates that it might play an important role in the proliferation, invasion, and metastasis of colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • GPAA1 could be a promising diagnostic biomarker for gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic target for gastric cancer
    ANIMAL & CELL MODELS