Citations for
GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway.
Zhang XX, Ni B, Li Q, Hu LP, Jiang SH, Li RK, Tian GA, Zhu LL, Li J, Zhang XL, Zhang YL, Yang XM, Yang Q, Wang YH, Zhu CC, Zhang ZG.
J Exp Clin Cancer Res 38(1):214. doi: 10.1186/s13046-019-1218-8. 2019
Stability of the transamidase complex catalyzing GPI anchoring of proteins.
Kawaguchi K, Sato T, Kondo S, Yamamoto-Hino M, Goto S.
Biochem Biophys Res Commun. May 7;512(3):584-590. doi: 10.1016/j.bbrc.2019.03.103. Epub 2019 Mar 23 2019
Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia.
Nguyen TTM, Murakami Y, Sheridan E, Ehresmann S, Rousseau J, St-Denis A, Chai G, Ajeawung NF, Fairbrother L, Reimschisel T, Bateman A, Berry-Kravis E, Xia F, Tardif J, Parry DA, Logan CV, Diggle C, Bennett CP, Hattingh L, Rosenfeld JA, Perry MS, Parker MJ, Le Deist F, Zaki MS, Ignatius E, Isohanni P, Lönnqvist T, Carroll CJ, Johnson CA, Gleeson JG, Kinoshita T, Campeau PM.
Am J Hum Genet 101(5):856-865. doi: 10.1016/j.ajhg.2017.09.020. 2017
Enzymatic mechanism of GPI anchor attachment clarified.
Kinoshita T.
Cell Cycle 13(12):1838-9. doi: 10.4161/cc.29379. Epub 2014 May 27. No abstract available. 2014
Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein's omega-site and the GPI lipid anchor's phosphoethanolamine.
Eisenhaber B, Eisenhaber S, Kwang TY, Grüber G, Eisenhaber F.
Cell Cycle 13(12):1912-7. doi: 10.4161/cc.28761. Epub 2014 Apr 17. 2014
Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer.
Chen G, Li SY, Cai HY, Zuo FY.
Genet Mol Res 13(1):499-507. doi: 10.4238/2014.January.21.19. 2014
Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma.
Ho JC, Cheung ST, Patil M, Chen X, Fan ST.
Int J Cancer 119(6):1330-7. 2006
A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.
Vainauskas S, Menon AK.
J Biol Chem 279(8):6540-5. Epub 2003 Dec 1. 2004
Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex.
Vainauskas S, Maeda Y, Kurniawan H, Kinoshita T, Menon AK.
J Biol Chem 277(34):30535-42. Epub 2002 Jun 06. 2002
Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron.
Inoue N, et al.
Cytogenet Cell Genet 84(3-4):199-205. 1999
Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins.
Hiroi Y, et al.
FEBS Lett 421 : 252-258. 1998
Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24.
Hiroi Y, et al.
Genomics 54 : 354-355. 1998
Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.
Hamburger D, et al.
J Cell Biol 129(3):629-39. 1995