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FLASH GENE
Symbol GNRHR contributors: mct/npt - updated : 10/12/2008
HGNC name gonadotropin-releasing hormone receptor
HGNC id 4421
Corresponding disease
GNRHR idiopathic hypogonadotropic hypogonadism
HH7 hypogonadotropic hypogonadism 7 with or without anosmia
Location 4q21.2      Physical location : 68.603.105 - 68.621.804
Synonym name
  • luliberin receptor
  • luteinizing hormone releasing horomone receptor
  • type I GnRH receptor
  • Synonym symbol(s) GRHR, LRHR, LHRHR, GNRHR1
    DNA
    TYPE functioning gene
    STRUCTURE 18.71 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CENPC1 4q13.2-q21.1 centromere protein C 1 BRDG1 4q13.1 centromere protein C 1 FLJ10808 4q13.3 hypothetical protein FLJ10808 LOC391658 4 similar to CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-ST) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3GalIA) (ST3O) (ST3GalA LOC391659 4 similar to hypothetical protein FLJ20397 GNRHR 4q21.2 gonadotropin-releasing hormone receptor HAT 4q13.3 airway trypsin-like protease LOC339967 4q13.3 hypothetical protein LOC339967 LOC339968 4q13.3 similar to RIKEN cDNA 9930032O22 gene LOC339970 4q13.3 similar to glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A LOC389208 4 similar to RIKEN cDNA 4732406D01 gene LOC391660 4 similar to RIKEN cDNA 9930019B18 gene DKFZp686L1818 4q13.3 hypothetical protein DKFZp686L1818 LOC391661 4 similar to UDP-glucuronosyltransferase YT521 4q13.3 splicing factor YT521-B MT2P1 4p11-q21 metallothionein 2 pseudogene 1 (processed) DESC1 4q13.3 DESC1 protein UGT2B29P 4q13 UDP glycosyltransferase 2 family, polypeptide B28 pseudogene UGT2B17 4q13 UDP glycosyltransferase 2 family, polypeptide B17 LOC345378 4q13.3 similar to UDP-glucuronosyltransferase 2B15 precursor, microsomal (UDPGT) (UDPGTH-3) (HLUG4) UGT2B15 4q13.3-q21.1 UDP glycosyltransferase 2 family, polypeptide B15 UGT2B10 4q13.3 UDP glycosyltransferase 2 family, polypeptide B10 LOC391662 4 similar to UDP-glucuronosyltransferase 2B7 precursor, microsomal (UDPGT) (3,4-catechol estrogen specific) (UDPGTH-2) LOC391663 4 similar to speckle-type POZ protein FLJ21934 4q13.3 hypothetical protein FLJ21934 LOC391664 4 similar to speckle-type POZ protein UGT2B27P 4q13 UDP glycosyltransferase 2 family, polypeptide B27 pseudogene UGT2B26P 4q13 UDP glycosyltransferase 2 family, polypeptide B26 pseudogene UGT2B7 4q13 UDP glycosyltransferase 2 family, polypeptide B7 LOC391665 4 similar to UDP-glucuronosyltransferase 2A1 precursor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5843 37 328 - Knollman (2008)
    3 splicing 5715 27 249 - Grosse, Knollman (2008)
  • may act a an inhibitor of GnRH-R signaling
  • using an alternate splice site in the coding region (a cryptic splicing acceptor site in exon 2) compared to variant 1, that results in a frameshift
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
     brainforebraincerebral cortex  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gnrhr
    ortholog to murine Gnrhr
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • mediating the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH)
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NBL1 is a novel autocrine/paracrine factor that modulates GNRHR function in pituitary gonadotropes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GNRHR , HH7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS