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FLASH GENE
Symbol GNRHR contributors: mct/npt - updated : 10/12/2008
HGNC name gonadotropin-releasing hormone receptor
HGNC id 4421
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gnrhr
    ortholog to murine Gnrhr
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • mediating the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH)
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NBL1 is a novel autocrine/paracrine factor that modulates GNRHR function in pituitary gonadotropes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GNRHR , HH7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS