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FLASH GENE
Symbol GNPDA1 contributors: - updated : 03-05-2004
HGNC name glucosamine-6-phosphate deaminase 1
HGNC id 4417
Location 5q21-q31      Physical location : 141.380.237 - 141.392.620
Synonym name
  • oscillin
  • glucosamine-6-phosphate isomerase
    • Synonym symbol(s) HLN, GNPI, GNPDA, KIAA0060, GPI, OSCL
    EC.number 3.5.99.6
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     5 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure Sp1 lacking a TATA box
    MAPPING cloned Y linked N status provisional
    Map cen - D5S500 - GNPDA1 - HARS - D5S2119 - D5S402 - D5S436 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Endocrinepancreasislet of Langerhans   
    Nervousbraindiencephalonhypothalamus highly
    Reproductivefemale systemovary   
     female systemuterus   
     male systemtestis  highly
    Skin/Tegumentskin    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text fetal_spleen, brain, kidney, heart, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer hexamer
    HOMOLOGY
    interspecies homolog to murine Gnpda1
    homolog to hamster oscillin
    intraspecies homolog to GNPDA2
    Homologene
    FAMILY glucosamine/galactosamine-6 phosphate isomerase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the reversible conversion of D-glucosamine-6-phosphate (GlcN6P) into D-fructose-6-phosphate (Fru6P) and ammonium
  • may be playing an essential role for egg activation and early embryo development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS