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FLASH GENE
Symbol GNG8 contributors: KTN/npt - updated : 09/09/2008
HGNC name guanine nucleotide binding protein (G protein), gamma 8
HGNC id 19664
Location 19q13.2-q13.3      Physical location : 47.137.333 - 47.137.939
Synonym name
  • G protein gamma 8 subunit
  • guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    • Synonym symbol(s) GNGT9, IG, SG, Gamma-9
    DNA
    TYPE functioning gene
    STRUCTURE 0.60 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 213 7.7 70 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to dog GNG8 (98.6 pc)
    homolog to rattus Gng8 (98.6 pc)
    homolog to murine Gng8 (98.6 pc)
    Homologene
    FAMILY G protein gamma family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • lipid-anchor
  • cytoplasmic side
    • basic FUNCTION
  • involved as a modulator or transducer in various transmembrane signaling systems
  • required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
  • hormone-mediated signaling
    • a component
  • prenylation
  • heterotrimeric G-protein complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS