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FLASH GENE
Symbol GMPR2 contributors: - updated : 10-01-2005
HGNC name guanosine monophosphate reductase 2
HGNC id 4377
Location 14q11.2-q21      Physical location : 24.701.647 - 24.708.445
Synonym name guanosine monophosphate reductase isolog
Synonym symbol(s) LOC51292, GMPRI
EC.number 1.6.6.8
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunethymus   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines all cancer cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
TIM barrel structure
HOMOLOGY
interspecies homolog to rattus Gmpr
intraspecies homolog to GMPR
Homologene
FAMILY IMPDH/GMPR family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,nucleus
basic FUNCTION
  • faciliting thermogenesis via regulatory effects on UCP1
  • functioning in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to a nucleotides, and in maintaining the intracellular balance of A and G nucleotides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS