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FLASH GENE
Symbol GMPR2 contributors: - updated : 10-01-2005
HGNC name guanosine monophosphate reductase 2
HGNC id 4377
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunethymus   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines all cancer cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
TIM barrel structure
HOMOLOGY
interspecies homolog to rattus Gmpr
intraspecies homolog to GMPR
Homologene
FAMILY IMPDH/GMPR family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,nucleus
basic FUNCTION
  • faciliting thermogenesis via regulatory effects on UCP1
  • functioning in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to a nucleotides, and in maintaining the intracellular balance of A and G nucleotides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS