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FLASH GENE
Symbol GLRA2 contributors: - updated : 19-12-2005
HGNC name glycine receptor, alpha 2
HGNC id 4327
Location Xp22.13      Physical location : 14.547.419 - 14.749.931
Synonym symbol(s) GLR, GLYR, GRA2
DNA
TYPE functioning gene
STRUCTURE 200.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map pter - DXS7100 - ARSD - DXS1060 - DXS1223 - DXS1043 - DXS8051 - PRPS2 - EGFL6 - BMX - GLRA2 - DXS1053 - DXS999 - DXS989 - SAT - DXS1048 - DXS1061 - cen
Authors GeneMap
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand gated ion (Cl) channel
  • four transmembrane segments
    • mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Glra2
    Homologene
    FAMILY ligand-gated ionic channel family
    CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • increasing the chloride conductance and thus producing hyperpolarization
  • signaling through GLRA2 plays a role in photoreceptor development in the retina, mediated by taurine
  • playing a role during the early stages of CNS development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS