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FLASH GENE

Symbol

GIGYF2

contributors: mct/npt - updated : 24-10-2016

HGNC name	GRB10 interacting GYF protein 2
HGNC id	11960

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PARK11 Parkinson disease 11
Location	2q37.1      Physical location : 233.562.014 - 233.725.285
Synonym name	trinucleotide repeat containing 15
	GYF domain containing 2
	PERQ amino acid rich, with GYF domain 2
	PERQ amino acid rich, with GYF domain 3
Synonym symbol(s)	FLJ23368, GYF2, KIAA0642, PERQ2, PERQ3, TNRC15, DKFZp686I15154, DKFZp686J17223

DNA

TYPE	functioning gene
STRUCTURE	163.27 kb     31 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D2S2158 - COL4A3 - D2S396 - D2S172 - D2S206 - D2S331 - TNRC15 - D2S2202 - D2S2338 - D2S2285 - AGXT - D2S125 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001103147 31 - 7952 NP_001096617 - 1320 - 2012 22751931 NM_015575 31 - 7959 NP_056390 - 1299 - 2012 22751931 NM_001103146 29 - 7819 NP_001096616 150.1 1299 - 2012 22751931 NM_001103148 28 - 7735 NP_001096618 - 1293 - 2012 22751931

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive mouth       highly Nervous brain         Reproductive female system ovary         male system testis     highly   male system prostate       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a GYF domain, conserved eukaryotic adaptor domain that recognize proline-rich sequences, interact with the GRB10 proline-rich region, and bind AGO2

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm

basic FUNCTION	may acting cooperatively with GRB10 to regulate receptor signaling
	EIF4E2-GIGYF2 are a cofactor in translational repression and mRNA decay by ZFP36
	upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	linked to IGF-I receptors by the GRB10 adapter protein following IGF-I stimulation
	GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins
	AGO2 interacting with GIGYF2 through the GYF domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PARK11

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   might contribute to the development of diabetes-associated cognitive disorder via negatively regulating IGF1R signaling pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     down-regulation of GIGYF2 expression may provide a potential novel approach to treat diabetes-associated cognitive impairment caused by aberrant IGF1R signaling pathway

ANIMAL & CELL MODELS

Heterozygous Gigyf2 +/- mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction